The NRF2 pathway is a cellular defense mechanism that plays a crucial role in protecting cells from oxidative stress and maintaining cellular homeostasis. NRF2 is a transcription factor that regulates the expression of genes involved in antioxidant defense, detoxification, and cell survival. Activation of the NRF2 pathway is important for protecting cells from damage caused by reactive oxygen species and other harmful molecules. Research on the NRF2 pathway has focused on understanding the molecular mechanisms that regulate its activity, as well as the potential therapeutic implications of targeting the pathway for the treatment of various diseases, including cancer, neurodegenerative diseases, and inflammatory conditions. Studies have also explored the role of the NRF2 pathway in aging and age-related diseases. Overall, research on the NRF2 pathway has provided valuable insights into the cellular mechanisms that protect against oxidative stress and maintain cellular health, and has the potential to lead to the development of new treatment strategies for a range of diseases.